Fifty years ago, horrific creatures dubbed as the "enemies of humanity" suddenly appeared around the world. To combat these threats, teenagers gifted with supernatural abilities called "Talents"—such as pyrokinesis and time travel—hone their powers at an academy on a secluded island. Nanao Nakajima, however, is quite different from the others on the island: he has no Talent. With many "Talented" teenagers around him, Nanao is often a target for bullying, but even so, he still strives to complete his training. Soon after, two transfer students, the mysterious Kyouya Onodera and the mind-reading Nana Hiiragi, join the class. But just as everyone starts blending as comrades-in-arms, mysterious disappearances begin to threaten the class's entire foundation. [Written by MAL Rewrite]

In Ikebukuro, the lives of its citizens continue intertwining with each other as if their fates are predestined. Mikado Ryuugamine is now one step closer to his goal of living an exciting life, and in turn, delves deeper into the darker side of Ikebukuro. After gaining absolute control over a former rival, he uses his newfound power as he pleases, purging the Dollars from the inside to mold it into the ideal organization. This proves to be as challenging as it sounds as Mikado must now deal with unwanted outside interference, most notably a re-emerging and dearly missed friend. Meanwhile, Izaya Orihara still has some schemes up his sleeve, although a rival information exchange center has proven to be quite the hindrance, lurking within everyone’s favorite downtown district. Undoubtedly, sooner or later, chaos will strike again. [Written by MAL Rewrite]