Glomerular disease following COVID-19 vaccination
Efforts to vaccinate the world's population against SARS-CoV-2 are underway and include the messenger RNA (mRNA) vaccines (Moderna mRNA-1273 and Pfizer-BioNTech BNT162b2). Emerging data, currently limited to case reports, suggest that de novo glomerular disease and relapse of pre-existing glomerular disease have occurred shortly after administration of the Pfizer and Moderna vaccines [1-13]. However, these events are overall rare, and a causal link with the COVID-19 vaccines is not established. Thus, we strongly encourage COVID-19 vaccination among patients with pre-existing glomerular disease, even if they are on immunosuppressive therapy. For patients who develop glomerular disease after the first dose of a mRNA vaccine, we advise a discussion of risk and benefits of further vaccination based upon the individual’s type and severity of glomerular disease and whether or not they are in remission by the time of the scheduled second dose.
See 'COVID-19: Issues related to acute kidney injury, glomerular disease, and hypertension', section on 'COVID-19 vaccine-associated glomerular disease' and 'COVID-19: Issues related to acute kidney injury, glomerular disease, and hypertension', section on 'COVID-19 vaccination in patients with glomerular disease'.
1. Anderegg MA, Liu M, Saganas C, et al. De novo vasculitis after mRNA-1273 (Moderna) vaccination. Kidney Int 2021.
2. Tan HZ, Tan RY, Jun Choo JC, et al. Is COVID-19 vaccination unmasking glomerulonephritis? Kidney Int 2021.
3. Lebedev L, Sapojnikov M, Wechsler A, et al. Minimal Change Disease Following the Pfizer-BioNTech COVID-19 Vaccine. Am J Kidney Dis 2021.
4. Maas RJ, Gianotten S, van der Meijden WAG. An Additional Case of Minimal Change Disease Following the Pfizer-BioNTech COVID-19 Vaccine. Am J Kidney Dis 2021.
5. D'Agati VD, Kudose S, Bomback AS, et al. Minimal change disease and acute kidney injury following the Pfizer-BioNTech COVID-19 vaccine. Kidney Int 2021.
6. Holzworth A, Couchot P, Cruz-Knight W, Brucculeri M. Minimal change disease following the Moderna mRNA-1273 SARS-CoV-2 vaccine. Kidney Int 2021.
7. Perrin P, Bassand X, Benotmane I, Bouvier N. Gross hematuria following SARS-CoV-2 vaccination in patients with IgA nephropathy. Kidney Int 2021.
8. Negrea L, Rovin BH. Gross hematuria following vaccination for severe acute respiratory syndrome coronavirus 2 in 2 patients with IgA nephropathy. Kidney Int 2021; 99:1487.
9. Rahim SEG, Lin JT, Wang JC. A case of gross hematuria and IgA nephropathy flare-up following SARS-CoV-2 vaccination. Kidney Int 2021.
10. Komaba H, Wada T, Fukagawa M. Relapse of Minimal Change Disease Following the Pfizer-BioNTech COVID-19 Vaccine. Am J Kidney Dis 2021.
11. Kervella D, Jacquemont L, Chapelet-Debout A, et al. Minimal change disease relapse following SARS-CoV-2 mRNA vaccine. Kidney Int 2021.
12. Schwotzer N, Kissling S, Fakhouri F. Letter regarding "Minimal change disease relapse following SARS-CoV-2 mRNA vaccine". Kidney Int 2021.
13. Aydin MF, Yildiz A, Oruc A, et al. Relapse of primary membranous nephropathy after inactivated SARS-CoV-2 virus vaccination. Kidney Int 2021.