The risk of developing cancer in patients with Barrett's esophagus increases with age and is higher in men, and in individuals with long segments (>3 cm) of Barrett's mucosa. H. pylori infection appears to protect the esophagus from gastroesophageal reflux disease, Barrett's esophagus, dysplasia in Barrett's esophagus, and esophageal adenocarcinoma, perhaps by causing a chronic gastritis that interferes with acid production. (See 'Risk and protective factors' above.)

●Traditionally, cancers in Barrett's esophagus were assumed to evolve gradually through a sequence of genetic and epigenetic alterations that gave the cells certain growth advantages, and caused morphological changes in the tissue that could be recognized on histopathology as dysplasia. It now appears that most tumors in Barrett's metaplasia develop though a "genome-doubled pathway" that can progress quickly to malignancy. (See 'Histologic changes' above and 'Molecular mechanisms' above.)

●Neoplastic progression observed in patients with Barrett's esophagus commonly includes alterations in the tumor suppressor genes p53 (also known as TP53) and p16 (also known as CDKN2A), and in the cyclin D1 protooncogene. (See 'Molecular mechanisms' above.)

>> H. pylori infection appears to protect the esophagus from gastroesophageal reflux disease
H. pylori, по-видимому, защищает пищевод от гастроэзофагеальной рефлюксной болезни? Может быть  неправильно прочитал

H. pylori strains that express cytotoxin-associated gene A (cagA) appear to be especially damaging to the stomach, and especially protective for the esophagus.

там же написано

@jul1asanctuary не видать тебя давно