Mapping out future breast cancer studies with a spatially resolved single cell atlas🗓
30 June 2021⏰
9AM PDT, 12PM EDT, 6PM CESTThe human breast consists of lobules connected to an intricate network of ducts that are surrounded by fatty tissues, designed to produce and transport milk to nourish offspring. Histopathology has identified 10 major cell types based on morphological features but has provided limited information on cell states—the transcriptional programs of cell types that reflect different biological functions.
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To improve our understanding of these cell types and states, we performed single cell and spatial gene expression analysis on healthy breast tissue samples from 24 women, creating a human breast cell atlas that will be an invaluable tool for understanding this important tissue in health and disease. In this virtual seminar, you will:✔️ Learn about the generation of an unbiased cell atlas of pathologically normal human breast tissue using a combination of single cell and spatial transcriptomics
✔️ Find out how single cell and single nucleus RNA-seq data from 248,687 cells and 89,301 nuclei was used to identify 12 cell types and over 36 cell states with different biological functions
✔️ Discover the utility of the cell atlas as an invaluable community reference for learning how normal cell types are reprogrammed in diseases such as breast cancer
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