anytime! does it pay off — is a vague question :) can you please elaborate what you mean. Is GraalVM node faster than normal node? — no, V8 is really-really good :) I think we're very close to v8 at peak performance in Enterprise. But the warmup is way-way longer.
GraalVM can run with giant heaps though, because you can leverage the GCs from HotSpot (really-really good ones), and you can mix your js with for example Java — so in certan scenarios that can give you quite a bit of CPU back.
NextJournal for example is rendering their react on server-side with GraalVM:
https://nextjournal.com/kommen/react-server-side-rendering-with-graalvm-for-clojure there are some very approximate numbers there