Vasiliy
From 21 days after the first dose of vaccine (the day of dose 2), 16 COVID-19 cases were confirmed in the vaccine group (of 14964 participants; 0·1%) and 62 cases were confirmed in the placebo group (of 4902 participants; 1·3%); vaccine efficacy was 91·6% (95% CI 85·6–95·2; table 2). The observed vaccine efficacy was greater than 87% in all age and sex subgroups. Notably, vaccine efficacy was 91·8% (67·1–98·3) in participants older than 60 years. There were no cases (vaccine group) and 20 cases (placebo group) of moderate or severe COVID-19 confirmed at least 21 days after dose 1; thus, vaccine efficacy against moderate or severe COVID-19was 100% (94·4–100·0). From 15 to 21 days after the first dose, efficacy was 73·6% (p=0·048), then from day 21, efficacy was 100% (p<0·0001; appendix p 11).
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