Первый Московский государственный медицинский университет имени И.М. Сеченова

The common co-occurrence of antibiotics and phages in both natural and engineered environments underscore the need to understand their interactions and implications for bacterial control and antibiotic resistance propagation. Here, aminoglycoside antibiotics that inhibit protein synthesis (e.g., kanamycin and neomycin) impeded replication of coliphage T3 and Bacillus phage BSP, reducing their infection efficiency and mitigating their hindrance of bacterial growth, biofilm formation and tolerance to antibiotics. For example, treatment with phage T3 reduced subsequent biofilm formation by E. coli liquid cultures to 53 ± 5% of the no-phage control, but a smaller reduction of biofilm formation (89 ± 10%) was observed for combined exposure to phage T3 and kanamycin. Despite sharing a similar mode of action with aminoglycosides (i.e., inhibiting protein synthesis) and antagonizing phage replication –albeit to a lesser degree, tetracyclines did not inhibit phages for bacterial control. Phage T3 combined with tetracycline…

Почему «ЭпиВакКорону» не стоит называть вакциной? Объясняет молекулярный биолог Константин Северинов