AP
А шо такоэ электрофильная реакция?
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2019 September 23
AP
Вы ж понимаете что где одно там и другое, да?
IC
А шо такоэ электрофильная реакция?
видимо, подразумевается, что "главная биомолекула" в роле нуклеофила
AP
А, ок
AP
Ну да, фридель-крафтс в природе не распространен ))
AZ
видимо, подразумевается, что "главная биомолекула" в роле нуклеофила
https://sci-hub.se/https://linkinghub.elsevier.com/retrieve/pii/S0022-2836(07)00961-8
Figure 5 shows that there are 132 instances of
nucleophile and nucleofuge functions (nucleophilic
covalent catalysis), but only 32 cases of electrophile
and electrofuge functions (electrophilic covalent
catalysis). This can be rationalised by the chemical
nature of the catalytic amino acid residues in
MACiE: they are uniquely able to stabilise the
catalytic states required for nucleophilic covalent
catalysis, whereas the states required for electrophilic covalent catalysis are less well stabilised and
thus much less common.
Figure 5 shows that there are 132 instances of
nucleophile and nucleofuge functions (nucleophilic
covalent catalysis), but only 32 cases of electrophile
and electrofuge functions (electrophilic covalent
catalysis). This can be rationalised by the chemical
nature of the catalytic amino acid residues in
MACiE: they are uniquely able to stabilise the
catalytic states required for nucleophilic covalent
catalysis, whereas the states required for electrophilic covalent catalysis are less well stabilised and
thus much less common.
AP
Надо почитать!
FG
Я в пути.
AZ
и вот это:
Finally, we demonstrate that the reason that nature really chose phosphate is due to interplay between two counteracting effects: on the one hand, phosphates are negatively charged and the resulting charge-charge repulsion with the attacking nucleophile contributes to the very high barrier for hydrolysis, making phosphate esters among the most inert compounds known. However
That is, the same charge-charge repulsion that makes phosphate ester hydrolysis so unfavorable also makes it possible to regulate, by exploiting the electrostatics.
https://www.ncbi.nlm.nih.gov/pubmed/23318152
Finally, we demonstrate that the reason that nature really chose phosphate is due to interplay between two counteracting effects: on the one hand, phosphates are negatively charged and the resulting charge-charge repulsion with the attacking nucleophile contributes to the very high barrier for hydrolysis, making phosphate esters among the most inert compounds known. However
That is, the same charge-charge repulsion that makes phosphate ester hydrolysis so unfavorable also makes it possible to regulate, by exploiting the electrostatics.
https://www.ncbi.nlm.nih.gov/pubmed/23318152
NK
Кому-нибудь нужно что-нибудь закодить за "еду" или просто опыт, в зависимости от размера задачи?
Zenome.io будет тебе рад:)
IC
и вот это:
Finally, we demonstrate that the reason that nature really chose phosphate is due to interplay between two counteracting effects: on the one hand, phosphates are negatively charged and the resulting charge-charge repulsion with the attacking nucleophile contributes to the very high barrier for hydrolysis, making phosphate esters among the most inert compounds known. However
That is, the same charge-charge repulsion that makes phosphate ester hydrolysis so unfavorable also makes it possible to regulate, by exploiting the electrostatics.
https://www.ncbi.nlm.nih.gov/pubmed/23318152
Finally, we demonstrate that the reason that nature really chose phosphate is due to interplay between two counteracting effects: on the one hand, phosphates are negatively charged and the resulting charge-charge repulsion with the attacking nucleophile contributes to the very high barrier for hydrolysis, making phosphate esters among the most inert compounds known. However
That is, the same charge-charge repulsion that makes phosphate ester hydrolysis so unfavorable also makes it possible to regulate, by exploiting the electrostatics.
https://www.ncbi.nlm.nih.gov/pubmed/23318152
ну так тут всё хорошо сформулировано)
AP
о, Варшел
NK
Ну да, фридель-крафтс в природе не распространен ))
Спасибо за отличную статью:)
IC
"отталкивает воду" != что-то типа "отталкивает нуклеофильно-ориентированную воду"
AZ
о, Варшел
AZ
и спустя 25 лет, в год нобелевки:
https://www.ncbi.nlm.nih.gov/pubmed/23318152
https://www.ncbi.nlm.nih.gov/pubmed/23318152
AP
и спустя 25 лет, в год нобелевки:
https://www.ncbi.nlm.nih.gov/pubmed/23318152
https://www.ncbi.nlm.nih.gov/pubmed/23318152
трололо! )
AP
еще спустя 25 лет надо ченить тиснуть на тему!
AZ
"отталкивает воду" != что-то типа "отталкивает нуклеофильно-ориентированную воду"
ну я сказал не так) я сказал нуклеофил воды) но думаю мы поняли друг друга)
IC
ну я сказал не так) я сказал нуклеофил воды) но думаю мы поняли друг друга)
рррр. ладно)